Inhibition of pyruvate decarboxylase from Z. mobilis by novel analogues of thiamine pyrophosphate: investigating pyrophosphate mimics.
نویسندگان
چکیده
Replacement of the thiazolium ring of thiamine pyrophosphate with a triazole gives extremely potent inhibitors of pyruvate decarboxylase from Z. mobilis, with K(I) values down to 20 pM; this system was used to explore pyrophosphate mimics and several effective analogues were discovered.
منابع مشابه
Gold(I)-catalysed synthesis of a furan analogue of thiamine pyrophosphate
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ورودعنوان ژورنال:
- Chemical communications
دوره 9 شماره
صفحات -
تاریخ انتشار 2007